Organelles

  • Chemists Create Clusters of Organelles by Mimicking Nature

    Two polymersomes assemble by DNA hybridization: the single DNA strands on the surface of the compartments interconnect, creating an extremely stable DNA bridge. University of Basel

    Scientists from the University of Basel have succeeded in organizing spherical compartments into clusters mimicking the way natural organelles would create complex structures. They managed to connect the synthetic compartments by creating bridges made of DNA between them. This represents an important step towards the realization of so-called molecular factories. The journal Nano Letters has published their results.

  • Designer Organelles in Cells Produce Synthetic Proteins

    Construction of an organelle in a living cell for protein biosynthesis. ill./©: Gemma Estrada Girona

     

    A research team led by biophysical chemist Professor Edward Lemke has engineered a designer organelle in a living mammalian cell in a new complex biological translation process. The created membraneless organelle can build proteins from natural and synthetic amino acids carrying new functionalities. For example, scientists might incorporate fluorescent building blocks into proteins via the organelle that allow a glimpse inside the cell using imaging methods. The research work now published in Science was a collaboration of Johannes Gutenberg University Mainz (JGU), the Institute of Molecular Biology (IMB) and the European Molecular Biology Laboratory (EMBL).