Heart disease

  • Blood flow under magnetic magnifier

    Arterial Spin Labeling allows to visualize vascular territories in the brain without the need of contrast agents – one of many applications. © Photo Fraunhofer MEVIS

    A training workshop at Fraunhofer MEVIS will deliver information about the possibilities of perfusion magnetic resonance imaging.

    When diagnosing strokes and heart diseases or looking at tumors, perfusion magnetic resonance imaging offers a gentler way to capture the blood flow circulation in the organs. However, the method is far from being implemented to its full potential at many clinics. The Fraunhofer Institute for Medical Image Computing MEVIS in Bremen, Germany is organizing a workshop entitled “Measurement of Perfusion and Capillary Exchange” from June 21 to 23 to promote adoption of the method. The event will provide information about its applications and the current state of research.

  • BMJ study shows: CT reduces cardiac catheterisations

    3D CT scan showing normal coronary arteries. Prof. Marc Dewey

    Over 3.5 million cardiac catheterisations are performed in Europe each year. A study jointly conducted by radiologists and cardiologists at Charité – Universitätsmedizin Berlin and published in today’s issue of The BMJ compares computed tomography (CT) with cardiac catheterisation in patients with atypical chest pain and suspected coronary artery disease (CAD). We talked about the study results with Professor Marc Dewey, the principal investigator of the study.

  • Cardiac diseases: when less is more

    PRECISE-DAPT Score. Department of Cardiology, Inselspital, Bern University Hospital

    Which patient will benefit most from a platelet inhibitor after a heart operation? The Department of Cardiology of Inselspital, Bern University Hospital, can answer this question with a new test, which has been published in "The Lancet".

    Spending less time in hospital, having to take less medication after surgery – both are concerns shared by most patients. In a study published this month, the Department of Cardiology of Inselspital addressed this concern. In accordance with the principle of weighing benefits and risks, upon which all medical treatments are based, it took an in-depth look at medicinal after-care from the patients’ perspective.

  • Discovery of a Key Regulatory Gene in Cardiac Valve Formation

    With the atria and major vessels removed, all four valves are clearly visible. Betts, J. Gordon (2013). Anatomy & physiology. pp. 787–846

    Researchers from the University of Basel in Switzerland have identified a key regulator gene for the formation of cardiac valves - a process crucial to normal embryonic heart development. These results are published in the journal Cell Reports today.

    The heart is the first functional organ that develops in vertebrate embryos. In humans, it starts to beat four weeks into the pregnancy. Unfortunately, congenital heart disease is one of the most common developmental abnormalities and the leading cause of birth defect-related deaths. These heart defects often involve malformations of cardiac valves, which are required to regulate the pressure and flow of blood in the cardiac chambers.

  • Engineered heart muscle for the treatment of heart failure

    Cardiac Muscle.

    MBM ScienceBridge GmbH successfully negotiated a license agreement between Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin (UMG) and the biotech company Repairon GmbH about commercial production and use of engineered human myocardium for heart failure repair. The production methods are based on the scientific work from the group of Prof. Dr. Wolfram-Hubertus Zimmermann, Director of the Institute for Pharmacology and Toxicology at the UMG.

  • Erstmals in Deutschland: Echtzeit-Simulatortraining für OP-Teams in Bad Oeynhausen

    Als erste Klinik in Deutschland führt das Herz- und Diabeteszentrum NRW, Bad Oeynhausen, Simulatortrainings für OP-Teams ein. (Foto: Laura Pippa).

    Was für Piloten schon lange zur Pflicht zählt, soll jetzt auch im OP-Saal zu größerer Sicherheit bei unerwarteten Ereignissen beitragen. Als erste und größte Herzchirurgie in Deutschland richtet das Herz- und Diabeteszentrum NRW in Bad Oeynhausen unter der Leitung von Prof. Dr. Jan Gummert ein Echtzeit-Simulatortraining für Operationsteams ein. Die Neuheit kommt aus den USA und wurde jetzt erstmals von Markus Rudloff, Tagungspräsident und Leiter der Kardiotechnik im Herz- und Diabeteszentrum NRW (HDZ NRW), Bad Oeynhausen, auf der Tagung der Deutschen Gesellschaft für Thorax-, Herz- und Gefäßchirurgie und der Jahrestagung für Kardiotechnik vom 11.-13. November in Weimar als integriertes, klinisches Pilotprojekt vorgestellt. Weltweit sind derzeit erst 30 Simulator-systeme dieser Art (Hersteller: Biomed Simulation Inc., San Diego) im Einsatz.

  • Heart examinations: Miniature particle accelerator saves on contrast agents

    Prof. Franz Pfeiffer and PD Dr. Daniela Münzel at the miniature synchrotron Munich Compact Light Source (MuCLS). Heddergott / TUM

    The most prevalent method for obtaining images of clogged coronary vessels is coronary angiography. For some patients, however, the contrast agents used in this process can cause health problems. A team at the Technical University of Munich (TUM) has now demonstrated that the required quantity of these substances can be significantly reduced if monoenergetic X-rays from a miniature particle accelerator are used.

    Soft tissues such as organs and blood vessels are nearly impossible to examine in X-ray images. To detect a narrowing or other changes in coronary blood vessels, patients are therefore usually injected with an iodinated contrast agent.

  • Herz-Bindegewebe unter Strom

    Wenige Nanometer breite Tunnel verbinden Muskel- und Nicht-Muskelzellen im Herzen. (Grün: Bindegewebszelle, Blau: Muskelzelle). Universitätsklinikum Freiburg

    Erstmals elektrische Kopplung von Muskel- und Nicht-Muskelzellen im Herzen nachgewiesen / Erkenntnisse könnten neue Therapieansätze bei Herzinfarkt und Herzrhythmus-Störungen ermöglichen / Veröffentlichung in der Fachzeitschrift PNAS. Es wurde bereits lange vermutet, aber nie bewiesen: Im Herzen sind Muskelzellen und Nicht-Muskelzellen elektrisch miteinander verbunden. Das zeigen nun erstmals Forscherinnen und Forscher des Universitäts-Herzzentrums Freiburg · Bad Krozingen (UHZ). Im Labor schleusten sie in unterschiedliche Typen von Herzzellen Moleküle ein, die bei Spannungsänderungen aufleuchten. Diese Licht-Signale konnten die Forscher nicht nur in Muskelzellen, sondern auch im Bindegewebe des Herzens nachweisen, wie es beispielsweise bei der Vernarbung des Herzens verstärkt gebildet wird.

  • Highly Sensitive Sensors to Measure the Heart and Brain Activity

    By applying a magnetic field, the bending beam vibrates. A permanently electrically charged electret (blue) pulls the bending beam. This way his vibrance gets stronger. Copyright: Marleen Schweichel

     

    Electrical signals measurements such as the ECG (electrocardiogram) can show how the human brain or heart works. Next to electrical signals magnetic signals also reveal something about the activity of these organs. They could be measured with little effort and without skin contact. But the especially weak signals require highly sensitive sensors. Scientists from the Collaboraive research Center 1261 "Magnetoelectric Sensors" at Kiel University have now developed a new concept for cantilever sensors, with the future aim of measuring these low frequencies of heart and brain activity. The extremely small, energy-efficient sensors are particularly well-suited for medical applications or mobile microelectronics. This is made possible by the use of electrets. Such material is permanently electrically charged, and is also used in microphones for hearing aids or mobile phones. The research team presented its sensor concept in a special edition of the renowned journal Nano Energy.

     

  • MHH-Forscher reparieren geschädigte Blutgefäße mit Nanopartikel-Therapie

    Gefäße der Halsschlagader im Mausmodell. Quelle: MHH/Sonnenschein.

    MHH-Wissenschaftler fördern Heilung von Gefäßinnenwänden mit mikroRNAs / Veröffentlichung in der Fachzeitschrift Circulation. Blutgefäße sind innen mit einer schützenden Zellschicht, dem Endothel, ausgekleidet. Im Laufe des Lebens nutzt sich diese Schicht ab, die Gefäßewände verdicken und verkalken. Diese Veränderungen sind häufig Ursache für Erkrankungen wie Herzinfarkt oder Schlaganfall. Forscher der Medizinischen Hochschule Hannover (MHH) haben eine neue Therapie zur Heilung derart geschädigter Gefäße entwickelt.

  • Mikrosensor hilft herzkranken Menschen

    Patient Mike Bartsch und DHZB-Kardiologe Dr. Felix Schönrath DHZB

    Am Deutschen Herzzentrum Berlin wird ein neuartiges Implantat eingesetzt, das direkt am Herzen den Blutdruck misst und drahtlos überträgt. Es ermöglicht den Ärzten eine bessere Überwachung von Patienten mit schwerer Herzschwäche.

  • Supervised Exercise Training Helps Patients with Heart Failure

    The major signs and symptoms of heart failure.

    Contrary to what was previously assumed, physical exercise does not lead to harmful ventricular enlargement. Researchers at the Technical University of Munich (TUM) and the Norwegian University of Science and Technology in Trondheim (NTNU) have disproved this earlier hypothesis and issued recommendations for designing a training program for persons with congestive heart failure. Congestive heart failure is among the most frequent causes of death in industrialized countries. As a consequence of this condition, the patient’s heart is no longer capable of adequately supplying the body with blood and oxygen. Until now, the prognosis for congestive heart failure has been poor and comparable to that of cancer.