Enhancers are regulatory regions of the DNA, giving rise to “long non-coding RNAs” (lncRNAs), which are known as crucial regulators of gene expression. Scientists from the Max Planck Institute for Molecular Genetics in Berlin now have shown that a lncRNA called A-ROD is only functional the moment it is released from chromatin into the nucleoplasm. In the current issue of Nature Communications the researchers demonstrate that the regulatory interaction requires dissociation of A-ROD from chromatin, with target specificity ensured within the pre-established chromosomal proximity. This can heavily influence our understanding of dynamic regulation of gene expression in biological processes.

Scientists take challenge of developing functional microdevices for direct access to the brain, spinal cord, eye and other delicate parts of human body. A tiny robot that gets into the human body through the simple medical injection and, passing healthy organs, finds and treats directly the goal – a non-operable tumor… Doesn’t it sound at least like science-fiction? To make it real, a growing number of researchers are now working towards this direction with the prospect of transforming many aspects of healthcare and bioengineering in the nearest future. What makes it not so easy are unique challenges pertaining to design, fabrication and encoding functionality in producing functional microdevices.

The NRW Nano Conference is Germany’s largest conference with international appeal in the field of nanotechnologies. It takes place every two years at changing locations. More than 700 experts from science, industry and politics meet for two days to promote research and application of the key technology at the network meeting.

In chemistry, a reaction is spontaneous when it does not need the addition of an external energy input. How much energy is released in a reaction is dictated by the laws of thermodynamics. In the case of the spontaneous reactions that occur in the human body this is often not enough to power medical implants. Now, scientists at the Max Planck Institute for Intelligent Systems in Stuttgart, together with an international team of researchers, found a way to boost the energy output by storing and bundling the energy of many spontaneous enzyme reactions. The work is published in the journal Nature Communications.

If certain signaling cascades are misregulated, diseases like cancer, obesity and diabetes may occur. A mechanism recently discovered by scientists at the Leibniz- Forschungsinstitut für Molekulare Pharmakologie (FMP) in Berlin and at the University of Geneva has a crucial influence on such signaling cascades and may be an important key for the future development of therapies against these diseases. The results of the study have just been published in the prestigious scientific journal 'Molecular Cell'.

Arming CRISPR/Cas systems with an enzyme that also controls the translation of genetic information into protein. CRISPR/Cas systems are known as promising “gene scissors” in the genome editing of plants, animals, and microorganisms by targeting specific regions in their DNA – and perhaps they can even be used to correct genetic defects.

Moisture can destroy mortar over time – for example when cracks form as a result of frost. A team of scientists at the Technical University of Munich (TUM) has found an unusual way to protect mortar from moisture: When the material is being mixed, they add a biofilm – a soft, moist substance produced by bacteria.

Oliver Lieleg usually has little to do with bricks, mortar and concrete. As a professor of biomechanics at the Institute of Medical Engineering (IMETUM) and the Department of Mechanical Engineering, he mainly deals with biopolymer-based hydrogels or, to put it bluntly, slime formed by living organisms.These include bacterial biofilms, such as dental plaque and the slimy black coating that forms in sewage pipes. “Biofilms are generally considered undesirable and harmful. They are something you want to get rid of,” says Oliver Lieleg. “I was therefore excited to find a beneficial use for them.”

Early detection of antibiotic resistant pathogens can be life-saving. DZIF-scientists at the Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, have developed an antibody-based diagnostic test, which can identify carbapenem-resistant Acinetobacter baumannii bacteria in only 10 minutes – in a process similar to a pregnancy test.

Friedrich Simmel und Aurore Dupin, researchers at the Technical University of Munich (TUM), have for the first time created artificial cell assemblies that can communicate with each other. The cells, separated by fatty membranes, exchange small chemical signaling molecules to trigger more complex reactions, such as the production of RNA and other proteins. Scientists around the world are working on creating artificial, cell-like systems that mimic the behavior of living organisms. 

UZH researchers have discovered a new way in which certain antibodies interact with the flu virus. This previously unknown form of interaction opens up new possibilities for developing better vaccines and more efficient medication to combat the flu. Fever, shivering, headaches, and joint pains – each year millions of people around the world are affected by the flu. While most people recover after a few days, the WHO estimates that each year between 250,000 and 500,000 people die from the disease.

Bacteria fight their competitors with molecular spear guns, the so-called Type VI secretion system. When firing this weapon they also unintentionally hit their own kind. However, as researchers from the University of Basel’s Biozentrum report in the journal Cell, the related bacteria strains benefit from coming under fire. They recycle the protein components of the spear guns and use these to build their own weapons.

The most deadly aspect of breast cancer is metastasis. It spreads cancer cells throughout the body. Researchers at the University and the University Hospital of Basel have now discovered a substance that suppresses the formation of metastases. In the journal Cell, the team of molecular biologists, computational biologists, and clinicians reports on their interdisciplinary approach. The development of metastasis is responsible for more than 90% of cancer-related deaths, and patients with a metastatic disease are considered incurable.

Scientists at the University of Basel have developed nanoparticles which can serve as efficient contrast agents for magnetic resonance imaging. This new type of nanoparticles produce around ten times more contrast than common contrast agents and are responsive to specific environments. The journal Chemical Communications has published these results.

• Evonik is conducting research on new composite materials for the fixation of fractured bones
• Bioresorbable polymers degrade naturally in the body, eliminating the need for additional surgery
• Medical implant technology is an attractive and growing market

Biofilms are generally seen as a problem to be eradicated due to the hazards they pose for humans and materials. However, these communities of algae, fungi, or bacteria possess interesting properties both from a scientific and a technical standpoint. A team from the Technical University of Munich (TUM) describes processes from the field of biology that utilize biofilms as ‘construction workers’ to create structural templates for new materials that possess the properties of natural materials. In the past, this was only possible to a limited extent.

Am Biomedizinischen Centrum (BMC) geht die Core Facility Bioimaging, eine Serviceeinheit für lichtmikroskopische Verfahren, offiziell in Betrieb – in einer neuartigen Kooperation mit dem Unternehmen Leica Microsystems.

Scientists from the University of Freiburg have developed materials systems that are composed of biological components and polymer materials and are capable of perceiving and processing information. These biohybrid systems were engineered to perform certain functions, such as the counting signal pulses in order to release bioactive molecules or drugs at the correct time, or to detect enzymes and small molecules such as antibiotics in milk. The interdisciplinary team presented their results in some of the leading journals in the field, including Advanced Materials and Materials Today.

For the first time ever, researchers at TU Graz and the Medical University of Graz have managed to functionally characterise the three-dimensional interaction between red-light receptors and enzymatic effectors. The results, with implications for optogenetics, have been published in Science Advances. The aim of optogenetics is to control genetically modified cells using light. A team of Graz scientists led by Andreas Winkler from the Institute of Biochemistry at TU Graz have set a milestone in the future development of novel red-light regulated optogenetic tools for targeted cell stimulation.

Forscher untersuchen Biomoleküle oft isoliert im Reagenzglas, und es ist fraglich, ob die Ergebnisse auf dicht gepackte Zellen übertragbar sind. Ein Team aus Bochum, Dortmund und Greifswald verfolgte die Faltung einer RNA-Struktur in der lebenden Zelle und verglich die Ergebnisse mit Tests im Reagenzglas.