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- Written by Johannes Gutenberg-Universität Mainz
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New technique using nuclear spin hyperpolarization of hydrogen paves the way for further advances in the field of MRI. Magnetic resonance imaging (MRI) is already widely used in medicine for diagnostic purposes. Hyperpolarized MRI is a more recent development and its research and application potential has yet to be fully explored. Researchers at Johannes Gutenberg University Mainz (JGU) and the Helmholtz Institute Mainz (HIM) have now unveiled a new technique for observing metabolic processes in the body. Their singlet-contrast MRI method employs easily-produced parahydrogen to track biochemical processes in real time. The results of their work have been published in Angewandte Chemie International Edition and chosen by the editors as a "hot paper", i.e., an important publication in a rapidly-developing and highly significant field.
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- Written by Universität Bayreuth
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Magnetic nanoparticles biosynthesized by bacteria might soon play an important role in biomedicine and biotechnology. Researchers of the University of Bayreuth have now developed and optimised a process for the isolation and purification of these particles from bacterial cells. In initial tests, magnetosomes showed good biocompatibility when incubated with human cell lines. The results presented in the journal "Acta Biomaterialia" are therefore a promising step towards the biomedical use of magnetosomes in diagnostic imaging techniques or as carrier in magnetic drug delivery applications.
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- Written by Matthias Bischoff
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The Beethoven’s deafness and its development are a riddle. In a previous article the authors (Luthe and Bischoff, 2020) suggested poisoning by ultrafine particles through lead corrosion of e.g. organ pipes. In the present article, they propose that Beethoven’s health problems, especially his deafness, were caused by a combination of exposure to lead-containing micro- and nanoparticles. In addition, high alcohol consumption weakened the defense against radical oxidative stress. The authors further hypothesize that the ear is a major portal of entry for nanoparticles, in this case causing lead poisoning of the inner ear.
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- Written by Matthias Bischoff
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In this article the authors (Luthe and Bischoff, 2020) connect recent findings in nano-toxicology with the investigations in Ludwig van Beethoven’s supposed saturnism. Namely, contradicting measurements of lead concentration in Beethoven’s hair and bone cannot be explained by the current hypothesis discussed among scientists. This mismatch may be called the key to the conundrum. It is also of broader interest to toxicologists, as the circumstances of Beethoven’s poisoning elucidate a general issue of particle uptake and resulting effects, which is quite neglected until now. They suggest that lead containing micro- and nanoparticles, i.e. lead oxides and acetate are the basis for the contradicting lead levels. The different portal of entry discriminates the concentrations in the bones when compared to the hair follicles. The authors also consider the source for these ultrafine lead-containing particles in Beethoven’s environment, and propose a complete explanation for his saturnism.