Reconstruction of the main structures forming the liver lobule: Central (CV) and Portal veins (PV), sinusoidal (magenta) and bile canaliculi (green) networks, and hepatocytes (random colours). Morales-Navarrete et al. / MPI-CBG

First and new realistic 3D model of the liver lobule since the year 1949: In 1949, Hans Elias pioneered the structural analysis of the mammalian liver tissue and proposed a model of the liver lobule, which is used to this day in textbooks. Almost 70 years later, researchers at the Max Planck Institute of Molecular Cell Biology and Genetics, the MPI for the Physics of Complex Systems, & the TU Dresden took advantage of novel microscopy developments, computer-aided image analysis, & 3D tissue reconstruction and created a new realistic 3D model of liver organization. Remarkably, they discovered that the liver features an organized structure, similar to liquid crystals.

Content of Lewy bodies: The inclusions in the neurons contain mainly a membranous medley instead of the anticipated protein fibrils. University of Basel, Biozentrum

An international team of researchers involving members of the University of Basel’s Biozentrum challenges the conventional understanding of the cause of Parkinson’s disease. The researchers have shown that the inclusions in the brain’s neurons, characteristic of Parkinson‘s disease, are comprised of a membranous medley rather than protein fibrils. The recently published study in “Nature Neuroscience” raises new questions about the etiology of Parkinson’s disease.

For routine applications in biomedicine and hospitals, the Jena research team integrated the multimodal imaging approach into an easy-to-use, multi-contrast nonlinear microscope (MediCARS). Leibniz-IPHT

A team of researchers from Jena is presenting a groundbreaking new method for the rapid, gentle and reliable detection of tumors with laser light at the leading trade fair "Laser World of Photonics" from 24 to 27 June 2019 in Munich. For the first time, the Leibniz Institute of Photonic Technology (Leibniz IPHT) will present a compact device for rapid cancer diagnosis during surgery. The optical method will help surgeons to remove tumors more precisely and could make cancer operations possible without a scalpel.

The codon-specific elongation model (COSEM) simulates protein synthesis. Scientific Reports

In a research co-operation, researchers of the Paul-Ehrlich-Institut (PEI) have developed a mathematical model which allows more accurate forecasts and improved output in the biotechnology-based protein synthesis in host organism. The new method offers many and varied applications in biotechnology including the development of vaccines. Scientific Reports has published an article on the results in its online version of 17 May 2019.