Signal receptor-containing vesicles (red) form on the inside of the cell membrane (brown) and bud off into the cell. Visualization: Thomas Splettstößer

If certain signaling cascades are misregulated, diseases like cancer, obesity and diabetes may occur. A mechanism recently discovered by scientists at the Leibniz- Forschungsinstitut für Molekulare Pharmakologie (FMP) in Berlin and at the University of Geneva has a crucial influence on such signaling cascades and may be an important key for the future development of therapies against these diseases. The results of the study have just been published in the prestigious scientific journal 'Molecular Cell'.

24-channel microscope "zenCELL owl”. InnoME GmbH

From August 29 to 31, 2018, the Medical Manufacturing Asia (MMA) takes place as a supplier trade fair in Singapore. The IVAM Microtechnology Network presents a joint pavilion at the fair. Here, international developers and manufacturers of medical device components present current technologies and products. The fair will be accompanied by a presentation forum, B2B meetings and a company visit.

Neoplastic cerebral organoid with GFP-positive tumor regions (green), which demonstrates glioblastoma-like cellularity. IMBA

For the first-time, researchers at IMBA- Institute of Molecular Biotechnology of the Austrian Academy of Sciences – develop organoids, that mimic the onset of brain cancer. This method not only sheds light on the complex biology of human brain tumors but could also pave the way for new medical applications.

 

Combining a tiny drug capsule with antibodies under acidic conditions results in the antibodies attaching to the drug carrier in a stable way. This makes targeting for nanocarriers possible. Stefan Schuhmacher

Scientists at the Mainz University Medical Center and the Max Planck Institute for Polymer Research (MPI-P) have developed a new method to enable miniature drug-filled nanocarriers to dock on to immune cells, which in turn attack tumors. In the future, this may lead to targeted treatment that can largely eliminate damage to healthy tissue.