Multiplexed Morse signals from cells
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How many sorts, in how many copies? The biochemical processes that take place in cells require specific molecules to congregate and interact in specific locations. A novel type of high-resolution microscopy developed at the Max Planck Institute for Biochemistry in Martinsried and Harvard University already allows researchers to visualize these molecular complexes and identify their constituents. Now they can also determine the numbers of each molecular species in these structures. Such quantitative information is valuable for the understanding of cellular mechanisms and how they are altered in disease states. The new technique is described in Nature Methods.