Pharmacy

  • Molecules change shape when wet

    The preferred structure of a crown ether changes when water molecules bind to it (dashed lines). © C. Pérez et al.

    Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water. In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max Planck Institute for the Structure and Dynamics of Matter at CFEL and from the Hamburg Centre for Ultrafast Imaging (CUI) show that water promotes the reshaping of crown ethers and biphenyl molecules, two classes of chemically fascinating molecules. Crown ethers are key systems in catalysis, separation and encapsulation processes, while biphenyl-based systems are employed in asymmetric synthesis and drug design.

  • Molekül-Motoren mit Licht-Antrieb

    Bahnbrechende Entwicklung: Zwei Nano-Maschinen (weiß) auf einer 8x8 Nanometer großen Kupferoberfläche (grau), aufgenommen bei -267° mit einem Rastertunnelmikroskop. In Gelb die Molekül-Modelle der Maschinen. Foto: Uni Graz/Grill

    ForscherInnen der Uni Graz steuern Nano-Maschinen auf Oberflächen. Ferngesteuerte Nano-Maschinen, angetrieben von einem Lichtstrahl, reinigen Oberflächen, bringen spezielle Pharmazeutika im Körper an ihren Zielort oder bauen elektronische Strukturen aus einzelnen Atomen. Dieser Zukunftsvision ist die Arbeitsgruppe von Univ.-Prof. Dr. Leonhard Grill vom Institut für Chemie der Karl-Franzens-Universität Graz einen großen Schritt nähergekommen: Dem Team ist es gelungen, einzelne molekulare Maschinen durch Laserlicht gezielt auf einer Oberfläche zu bewegen und währenddessen zu beobachten. Die Ergebnisse der Studie werden in der nächsten Ausgabe des Magazins „ACS Nano“ publiziert und sind online bereits veröffentlicht.

  • Monsanto takeover a “major challenge” for Bayer

    Bayer takes over Monsanto. © Nanobay

    Lars Schweizer, Professor for Strategic Management at Goethe University Frankfurt, calls the planned takeover of Monsanto by German pharmaceuticals giant Bayer a major challenge.

  • Multi-organ platform for risk assessment of nanomaterials - Fraunhofer IBMT in project HISENTS

    Logo HISENTS

    European scientists develop a multimodular microchip platform for predicting the behaviour of nanomaterials in the body. Nanomaterials are already part of everyday life in our modern society. New applications, along with continuously rising quantities being produced, have led to an increased exposure to nanomaterials for both people and the environment. Predicting the behaviour of nanomaterials in organisms and extensive risk assessments are currently difficult because we are missing prediction models.

  • Worrying traces of resistant bacteria in air

    Two photos taken in the same location in Beijing in August 2005. The photograph on the left was taken after it had rained for two days. The right photograph shows smog covering Beijing in what would otherwise be a sunny day.

    Polluted city air has now been identified as a possible means of transmission for resistant bacteria. Researchers in Gothenburg have shown that air samples from Beijing contain DNA from genes that make bacteria resistant to the most powerful antibiotics we have. “This may be a more important means of transmission than previously thought,” says Joakim Larsson, a professor at Sahlgrenska Academy and director of the Centre for Antibiotic Resistance Research at the University of Gothenburg.