Drug Targeting

  • Better Contrast Agents Based on Nanoparticles

    Scientists at the University of Basel have developed nanoparticles which can serve as efficient contrast agents for magnetic resonance imaging. This new type of nanoparticles produce around ten times more contrast than common contrast agents and are responsive to specific environments. The journal Chemical Communications has published these results.

  • COMPAMED 2016 connected medical devices and people

    Materialise NV from Belgium speaking on “Innovation in 3D Printed Wearables” at COMPAMED HIGH-TECH Forum 2016. IVAM

    Miniaturized connected systems and outstanding business contacts: forming networks on both technical and business level was one of the key features of COMPAMED 2016, the international trade fair for suppliers and manufacturers of medical technologies. This trend was visible at and enhanced by the joint trade fair booth of the IVAM Microtechnology Network in hall 8a, the accompanying presentation forum and numerous B2B meetings between companies from Germany and Japan.

  • Hepatitis C and HIV prophylaxis: microwave reduces viral transmission in the drugs scene

    PD Dr. Eike Steinmann und Anindya Siddharta. TWINCORE/Romy Weller

    Infections with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) among people who inject drugs (PWID) are a global health problem. For example, sharing of drug preparation equipment within this population contributes to more than 80% of newly acquired HCV infections. As a response to these circumstances, scientists at TWINCORE validated a simple and safe method to reduce the risk of viral transmission, namely by microwave irradiation. This method has been published recently in Scientific Reports.

  • Molecules change shape when wet

    The preferred structure of a crown ether changes when water molecules bind to it (dashed lines). © C. Pérez et al.

    Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water. In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max Planck Institute for the Structure and Dynamics of Matter at CFEL and from the Hamburg Centre for Ultrafast Imaging (CUI) show that water promotes the reshaping of crown ethers and biphenyl molecules, two classes of chemically fascinating molecules. Crown ethers are key systems in catalysis, separation and encapsulation processes, while biphenyl-based systems are employed in asymmetric synthesis and drug design.

  • Successfully Treating Genetically Determined Autoimmune Enteritis

    Poor to moderately differentiated adenocarcinoma of the stomach. H&E stain.

    Using targeted immunotherapy, doctors have succeeded in curing a type of autoimmune enteritis caused by a recently discovered genetic mutation. This report comes from researchers at the Department of Biomedicine of the University of Basel and University Hospital Basel. Their results raise new possibilities for the management of diarrhea, which is often a side effect of melanoma treatment. Immunodeficiencies can arise due to gene mutations in immune system proteins. As such mutations rarely occur, these immunodeficiencies often go unrecognized or are detected too late for effective treatment. Currently, there are more than 300 different known genetically determined immunodeficiencies, with new examples being described almost every week.